Research

These pages give an overview of my past and present research interests. I am currently lecturer in chemical-biology at Cardiff University in Wales, where my research interests include synthesis of guanidine amino acids, synthesis of topologically diverse peptide analogues, engineering of nucleic acid binding proteins and mass spectrometric structure determination.

I studied chemistry at the University of Oxford, and for my fourth year project worked in the Inorganic Chemistry Laboratory on ion-pair receptors with Prof. Paul Beer. I moved to the Department of Chemistry at the University of Cambridge to do a Ph.D. on the chemistry of rhodium porphyrins and porphyrin self-assembly with Prof. Jeremy Sanders.

I was a postdoc at the Scripps Research Institute with Prof. Reza Ghadiri for two years researching, amongst other things, the use of ion trap mass spectrometry for analysis of combinatorial libraries of cyclic peptide antimicrobials. Other projects involved the engineering of binding and catalytic sites into the hydrophobic cores of leucine zipper peptides.

I spent a further period back at the University of Cambridge with Dr Shankar Balasubramanian working on recognition of DNA quadruplexes using proteins and small molecules. I used an ELISA to screen zinc finger proteins and small peptides against various quadruplexes derived from sequences found within the human genome. Other areas of interest include the use of peptide-acridine conjugates for recognition of specific quadruplex folds.

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Copyright ©2010 James E. Redman. All rights reserved.